Coumarin derivatives can prevent replication of the hepatitis C virus by inducing an interferon antiviral response

Inhibiting Hepatitis C

Light Controlled Insulin Release
US scientists developed a drug depot which, upon exposure to light, releases insulin at appropriate times and amounts

Hydrogen Bonds Fight HIV Mutations
Interactions between water and rilpirivine’s cinnamonitrile group render this drug effective against mutant HIV strains

Twenty Years On, Still Just Saying NO
Nitrogen(II) oxide plays a key role in vasodilation, sexual arousal, and cardiac activity, but how much do we really know about NO concentrations?

A Full Stack with Protein Amides
Investigation of π-stacking interactions of protein amides could improve rational drug design

Safely Delivering α-Generator Radionuclides
Gold coated lanthanide phosphate nanoparticles safely deliver the alpha-generator radionuclide 225Ac to target tissues

Opening Doors in TB Drug Discovery
Open-source compound library at GSK identifies 177 small-molecule leads for anti-tuberculois (TB) research

Tumor Selective Polyamide
A hairpin pyrrole-imidazole polyamide prevents tumor growth without affecting health tissues

Most Sustainable Companies
Corporate Knights announced its Global 100 list of the world’s most sustainable corporations at the World Economic Forum in Davos

Angewandte Chemie 5/2013: It Just Works!
Overview of the latest issue of Angewandte Chemie