Amlexanox is a selective inhibitor of the kinases TBK1 and IKK-ε and it counteracts obesity and related disorders

Inhibiting Obesity

Angewandte Author Profiles February 2013
Licheng Sun, Peter J. Sadler, Manuel Alcarazo, Tomislav Rovis, Jieping Zhu, Hisashi Yamamoto, and Jun-An Ma were interviewed in February

Streamlined Anti-Cholesterol Drug Synthesis
Five steps have been removed from the synthesis of Atorvastatin, a widely used drug for lowering cholesterol

John LaMattina: 30 Years in Pharma
John LaMattina, former President, Pfizer Global R&D, on the changes, challenges, and misconceptions in the pharma industry

Do the Pain-Free Twist
Twisted crystals of aspirin point the way to a better understanding of the polymorphic forms of pharmaceuticals

Angewandte Chemie 10/2013: Celebrate with Us!
Overview of the Anniversary Symposium issue of Angewandte Chemie

Donation of Most Well Known German Chemical Journals
Bound volumes of Angewandte Chemie, Nachrichten aus der Chemie, and Chemie in Unserer Zeit will be given away

(R)-2-Hydroxyglutarate: A Leukemic Enantiomer
(R)-2-hydroxyglutarate promotes acute myeloid leukemias’ development but its effects can be pharmacologically blocked

Red Light for Breast Cancer Metastasis
Sipholenol analogues revealed as novel scaffolds for drugs that inhibit breast cancer cell migration and invasion

Sensing Danger for an Active Immune Response
cGAMP synthase senses microbic DNA molecules and acts as an alarm signal which activates immune defenses