Amlexanox is a selective inhibitor of the kinases TBK1 and IKK-ε and it counteracts obesity and related disorders
Inhibiting Obesity
Angewandte Author Profiles February 2013
Licheng Sun, Peter J. Sadler, Manuel Alcarazo, Tomislav Rovis, Jieping Zhu, Hisashi Yamamoto, and Jun-An Ma were interviewed in February
Streamlined Anti-Cholesterol Drug Synthesis
Five steps have been removed from the synthesis of Atorvastatin, a widely used drug for lowering cholesterol
John LaMattina: 30 Years in Pharma
John LaMattina, former President, Pfizer Global R&D, on the changes, challenges, and misconceptions in the pharma industry
Do the Pain-Free Twist
Twisted crystals of aspirin point the way to a better understanding of the polymorphic forms of pharmaceuticals
Donation of Most Well Known German Chemical Journals
Bound volumes of Angewandte Chemie, Nachrichten aus der Chemie, and Chemie in Unserer Zeit will be given away
Angewandte Chemie 10/2013: Celebrate with Us!
Overview of the Anniversary Symposium issue of Angewandte Chemie
(R)-2-Hydroxyglutarate: A Leukemic Enantiomer
(R)-2-hydroxyglutarate promotes acute myeloid leukemias’ development but its effects can be pharmacologically blocked
Red Light for Breast Cancer Metastasis
Sipholenol analogues revealed as novel scaffolds for drugs that inhibit breast cancer cell migration and invasion
Sensing Danger for an Active Immune Response
cGAMP synthase senses microbic DNA molecules and acts as an alarm signal which activates immune defenses