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Experiment!: Planning, Implementing and Interpreting

100th Anniversary: Clemmensen Reduction
The Clemmensen reduction of ketones and aldehydes is the simplest direct method for converting the carbonyl group into a methylene group

Organolithium Cross-Coupling
Practical method for the fast and highly selective direct cross-coupling of organolithium reagents has been developed

Easy Demetalation of Porphyrins
A simple, mild, methodology for the transformation of nickel porphyrins to the corresponding free-base porphyrins

Most Accessed Articles: May 2013
The most-accessed chemistry articles from ChemPubSoc Europe and GDCh journals for May 2013

How to Determine a Reaction's Usefulness
A way to analyze novel organic reactions and determine whether they will have wide or limited utility in organic syntheses has been developed

Science on the Market: What Does Competition Do to Research?
Michael Hampe, ETH Zurich, Switzerland, argues that scientists should not oversell their work in the pursuit of competitive funding

New Route for Large-Scale Graphene Production
In his 1000st paper Fraser Stoddart describes a direct exfoliation of graphene sheets from graphite in water

Targeting Cholera Toxin
The synthesis and initial biological evaluation of a calixarene-based inhibitor for cholera toxin has been developed

The Fastest and the Brightest Fluorescent Probe
BODIPY–tetrazine derivatives as superbright bioorthogonal turn-on probes