Fentanyl is a highly potent synthetic opioid used for pain relief in medical settings but is also widely abused

What is Fentanyl?

Pt-Catalyzed Hydroboration of Terminal Alkynes: A Regioselective Approach to Vinyl Boronates
A platinum-catalyzed hydroboration method that enables highly selective (E)-1,2-vinyl boronate synthesis, overcoming heteroatom coordination challenges

Faster, Cheaper, Smarter Thioxanthone Synthesis
Novel method to prepare complex thioxanthones from relatively simple and accessible precursors

Solvent-Controlled, Silver-Catalyzed Cross-Coupling
Reaction of cyclic aldimines and α-imino-oxy acids gives either nitriles with a cyclic imine or ring-opened oxonitriles

Biomolecule Precursors Found in Asteroid Sample
Samples from asteroid Bennu contain organic compounds, including amino acids and nucleobases

Happy Birthday, Klaus Roth!
Author of popular chemistry articles and books and Professor at Freie Universität Berlin, Germany, celebrates his 80th birthday

Total Synthesis of Ukabamide, a Drug Candidate against Sleeping Sickness
Lipopeptide from marine cyanobacteria could lead to new antitrypanosomal drugs

New Class of Carbon-Centered Diradicals Discovered
Monosubstituted carbon atom stabilized by a phosphine shows a triplet ground state

Nickel-Catalyzed Electrochemical Sulfuration of Alkyl Alcohols
Thiolation using pyridyl thioesters with a broad substrate scope

Helical, Bowl-Shaped Extended Quintulene
Chiral compound combines helicene and quintulene shapes