In-situ activation of both substrate and reductant

Practical Reduction of Carboxylic Acids
![On-Surface Synthesis of Aza[3]radialenes](https://www.chemistryviews.org/wp-content/uploads/legacy/common/images/thumbnails/source/17f18ebd28c.jpg)
On-Surface Synthesis of Aza[3]radialenes
Direct conversion of isocyanides via [1+1+1] cycloaddition

Neutral Diboron Analogues of Cyclopropanes
Diboriranes containing fluorenylidene and NHC groups studied

Efficient Cu(II)-Catalyzed Method for the Synthesis of Heterobiaryls
General strategy provides access to useful ligands

Total Synthesis of (−)-Magnoshinin and (+)-Merrilliaquinone
Late-stage oxidative functionalization used as a key synthetic step

Deaminative Alkylation of Phosphines Using Benzylamines
Visible-light photoredox catalysis used to prepare tertiary phosphines

Cross-Coupling Amides with Polyfluoroarenes
Deoxygenative reaction of aromatic amides gives polyfluoroaryl amines

Copper-Catalyzed Path to Trifluoromethylated Azaheterocycles
Alkene trifluoromethylation triggers a nitrile insertion/remote functionalization relay process

Angewandte Chemie 9/2022: Learn and Apply
Overview of the latest issue of Angewandte Chemie

New Type of Chiral Super Brønsted C–H Acid
BINOL-derived compounds for asymmetric Brønsted acid catalysis