First enantiospecific total synthesis of astellatol, a rare pentacyclic sesterterpenoid

Total Synthesis of Astellatol

150 Years Alfred Wöhlk
Despite many efforts, the mechanism of this still-used detection reaction from 1904 is still unknown

Better Cas9 for CRISPR Gene-Editing
Improved Cas9 protein could work on more sites in the genome with fewer unwanted effects

Platinum Drugs Also Bind to Proteins
Photoactivated platinum complexes shown to react with peptides, not just DNA

DNA Methyltransferase Inhibitors Fight Cancer
Potential nucleic acid drug lead for cancer therapy and useful chemical probe for studies of epigenetics

Angewandte Chemie 9/2018: Hot Stuff
Overview of the latest issue of Angewandte Chemie

Merck Invests in Startups
Merck and three partners start ExploreBio, a € 20 million pre-seed investment initiative in Israel

Better Characterization of Heterogeneous Biocatalysts
Single-particle methods for monitoring the structure and function of enzymes

CRISPR Patents for Merck
Patents in South Korea and Israel cover integration of an external DNA sequence into the chromosome of eukaryotic cells

Metalloenzyme for Water Oxidation
Iridium-modified carbonic anhydrase catalyzes water oxidation