Hybrid lipoic acid derivatives attack prion disease on multiple fronts suggesting possible targets for treatment

Multitarget Drugs against Prion Diseases

Nano Flower Power!
Flower-like dipeptide template enables nanoflake film formation - expected to broaden application of biomaterials in surface science

Blocking Bone Resorption
Matrix metalloproteinase inhibitors with bisphosphonate moiety show promise for treating tumor-induced bone disease

Perfect Host for Tetrathiafulvalene
New cyclic rotaxane that encapsulates tetrathiafulvalene also opens way for new topologically interesting systems

Most Accessed Articles: February 2011
The most-accessed chemistry articles from ChemPubSoc Europe and GDCh journals for February 2011

Doing Away with the Chaperone
New compound which destabilizes the molecular chaperone, heat-shock protein 90, has anticancer potential

Rapid Approach to Diverse Alkaloid-Like Compounds
A rapid approach to diverse alkaloid-like compounds which may lead to novel biological active small molecules

Valinomycin’s Preferred Conformation
Antibiotic’s backbone monitored by Raman optical activity to show preferred conformations in dioxane and methanol

Ambient CO2 Fixation
The ambient fixation of carbon dioxide can be achieved by converting it to cyclic carbonates with a ZnIIsalphen catalyst

Sensitive to Oxygen
New class of phosphorescent iridium(III) porphyrin complexes leads to tunable oxygen indicators