Binding RNA Drug Targets Using Spirocycles
New azaspirocycles with potential applications in drug discovery
Triel Bonds: New Pathway to Pentacoordinate Carbon
Study provides the first evidence of a pentacoordinate carbon in a stable complex, offering insights relevant to chemical bonding and biological methyl transfer processes
Selective Photocatalytic Benzene Oxidation
Iron-carbon nitride fragments used for the conversion of benzene to phenol
Synthesis of Axially Chiral Diaryl Aldehydes
Chiral phosphoric acid catalyst promotes formation of useful precursors for the synthesis of axially chiral compounds
“Bushy-Tailed” Disinfectants
Multicationic quaternary phosphonium compounds act as novel disinfectants with potent bioactivities and low toxicity
New Tetracyclic Ring Systems Synthesized
Five new heterocyclic ring systems that could have uses in medicinal chemistry
A New Chapter in Magnetism: The Role of Symmetry in Luminescent Yb3+ Complexes
Although the prolate single molecule magnets known from the textbook have large ground state splittings, this does not lead to strong magnetism
Silylation and Germylation of Azauracils
New protocol can be used for the late-stage functionalization of complex, drug-like molecules under mild conditions
New Cleavable Linker Design for Targeted Drug Therapy
Physiological thiol gradient between extra- and intracellular areas used to trigger novel cleavable linkers
Sustainable Aqueous Calcium-Ion Battery
Highly stable aqueous battery based on saturated CaCl2 with excellent fast charging capabilities developed
Cell-Penetrating Peptides Deliver Antimalaria Drugs
Peptide-drug conjugates provide an approach for developing new malaria treatments
Redox Cycling with Tellurium
Lewis superacidic organotellurenyl cation activates Si–H bonds
Nickel-Doped Bi2O2CO3 Nanosheets for Efficient Nitric Oxide Removal
The introduction of nickel ions improves photocatalytic performance under visible light
Understanding Polymerization in Extraterrestrial Ices
How can complex organic molecules like paraldehyde be synthesized in extraterrestrial ices?
3D-Printed Toolkit Enhances ElectraSyn Functionality
Expanded range and reproducibility for electrosynthesis
New Cationic Antimicrobial Octapeptides
Tryptophan-containing members of an alternative class of antibiotics show broad-spectrum activities
Selectively Thiolating Electron-Rich Arenes and Heteroarenes
A novel catalytic system that enables the regioselective thiolation of arenes with sulfonyl hydrazides, yielding para-thio-substituted products efficiently
Photocatalytic Hydrogen Release for Enzymatic Synthesis
A novel system combines light-triggered hydrogen release from formic acid with enzymatic hydrogenation, enabling controlled chemical synthesis under mild conditions
Niobium-Doped Tungsten Oxide Nanospheres for Hydrogen Evolution
Straightforward one-pot solvothermal approach gives an electrocatalyst with high activity