Directed evolution of enzymes for nitrogen functionalization

Enzyme Used to Insert Nitrogen into Unactivated C–H Bonds

Nitrous Oxide Used as an Oxygen Transfer Agent
Catalytic synthesis of cycloalkanols under mild conditions

Amide N-Arylations Under Mild Conditions
Nickel-photoredox catalysis helps to overcome the low nucleophilicity of amides

Borolide Sandwich Complex as a High-Performance Single-Molecule Magnet
Dianionic borolide ligands exert strong ligand fields on lanthanide ions

First Enantioselective Total Synthesis of (+)-Lucidumone
Scalable 13-step preparation of natural product

Enantioselective Hydroselenation of Styrenes
Rh-hydride catalyst favors formation of branched isomers

Enzyme Combined with Redox Mediator for C–H Activation
Horseradish peroxidase, hydrogen peroxide, and N-hydroxyphthalimide used for the functionalization of alkylbenzenes

Synthesis of Limonene Carbonates in Continuous Flow
Ionic liquid-catalyzed reaction with supercritical CO2 as solvent and reactant

Turning a Benzene Ring into a Pyridine
Direct transformation of aryl azides to aminopyridines via nitrogen insertion and carbon deletion

Fluorescence-Based Analysis Used to Measure Recycled Plastic Content
Aggregation of fluorescent tag enables quantitative tracking of recycled material