In this issue, L. Yuan et al. review the imaging of chemistry in individual organelles with fluorescent probes. How can small-molecule probes be targeted to elucidate functionality? In a Minireview, S. P. Marsden et al. evaluate new chemistry to drive molecular discovery. The Highlight deals with the mechanism of biological methane-forming reactions (S. Shima). In his Editorial, Peter Gölitz discusses the development of Angewandte Chemie and editorial policies regarding color cost and preprints.

In the Communications section, C. J. H. Porter et al. present glyceride-mimetic prodrugs that avoid first-pass metabolism and enhance oral bioavailability (see picture). P. A. Levkin et al. succeeded in UV-induced disulfide formation and reduction for photopatterning. M. D. Smith et al. present a counterion-directed approach to the Diels–Alder paradigm: a cascade synthesis of tricyclic fused cyclopropanes.

• Angewandte Chemie 44/2016: New Paradigms,
  Angew. Chem. Int. Ed. 2016, 55 (44).