In this issue, R. Riedl et al. review the targeting of antibiotic resistance. What promise do structure-based and mechanism-based approaches as well as interventions into the genome hold? In a Minireview, T. Weil et al. discuss diamond quantum devices in biology.

In the Communications section, C. Giansante et al. look at the dynamic interface of PbS quantum dots (see picture). Y. Wang et al. describe molecularly regulated reversible DNA polymerization. K. Tanaka et al. succeeded in rhodium-catalyzed cross-cyclotrimerizations and dimerizations of allenes with alkynes, and G. Schneider et al. used computational de novo design to go from from natural products to synthetic mimetics.

• Angewandte Chemie 23/2016: Resistance is Futile,
  Angew. Chem. Int. Ed. 2016, 55 (23).