In this issue, B. A. Grzybowski et al. review computer-assisted synthetic planning. How can computers design synthetic pathways to non-trivial targets, such as Taxol? In a Minireview, B. G. Davis et al. discuss the 50-year odyssey from chemical to post-expression mutagenesis.

In the Communications section, I. Siepmann et al. show how to identify sorbents for sweetening of highly sour natural gas (see picture). C. Uyeda et al. present well-defined models for dinuclear intermediates of the Pauson–Khand reactions, and M. Mack et al. identified the key enzyme of roseoflavin biosynthesis.

• Angewandte Chemie 20/2016: From Sour to Sweet,
  Angew. Chem. Int. Ed. 2016, 55 (20).