In this issue, L. Jullien et al. review self-immolative spacers. How do they ensure the temporally tailored cleavage of two chemical bonds on activation for drug release? The Highlight by R. Mitra and K.-R. Pörschke deals with the chemistry and catalytic activity of organonickel(IV) compounds. J. A. C. Clyburne et al. comment on the crystallographic snapshot of an intermediate in the activation of CO₂ discussed by G. S. McGrady et al. in issue 1.

In the Communications section, A. N. Cammidge et al. present a synthesis of meso-substituted subphthalocyanine–subporphyrine hybrids (see picture). J. Singh and J. B. Ugaonkar propose a model for prion protein misfolding. J. Dai and X. C. Zeng predict a titanium trisulfide monolayer to be a direct-gap semiconductor with ultrahigh electron mobility, and W. P. Unsworth et al. describe a direct access to spirocylic scaffolds.

• Angewandte Chemie 26/2015: Well Timed,
  Angew. Chem. Int. Ed. 2015, 54 (26).