In this issue, C. O. Kappe et al. review continuous-flow techniques for the manufacture of active pharmaceutical ingredients. How can reactions be run safely under harsh conditions and involving hazardous intermediates? The Highlight by F. von Nussbaum and R. D. Süssmuth deals with multiple attacks on bacteria by a new antibiotic.

In the Communications section, P. Fischer et al. show how to dynamically include metal nanoparticles inside nanocups by complexation (see picture). S. Yamaguchi et al. present a planarized triphenylborane mesogen which forms a columnar liquid-crystalline phase and has ambipolar charge-carrier transport properties. M. Fujita et al. succeeded in the synthesis of the longest helicene reported to date, and J. Yuan et al. introduce an aqueous manganese dioxide ink for paper-based capacitive energy storage.

• Angewandte Chemie 23/2015: With the Flow,
  Angew. Chem. Int. Ed. 2015, 54 (23).