In this issue, K. Itami et al. review the construction of heptagon-containing molecular nanocarbons. What is the fascination around their structural, physical, and optoelectronic properties about? The Minireview deals with the parahydrogen-induced polarization of amino acids. (J.-B. Hövener et al.), and A. Sarkar and K. Mandal highlight repurposing an antiviral drug against SARS-CoV-2 main protease. In their Editorial, M. Wiechen and other members of the Angewandte editorial team introduce two new article types: Scientific Perspectives and Viewpoint Articles.

In the original research section, R. Yang et al. describe a glucose-powered activatable nanozyme that breaks pH and H₂O₂ limitations for the treatment of diabetic infections (see picture). S. Jung and H. J. Yoon used mechanical force to transform aziridine into imine. J. C. Lewis et al. engineered dirhodium artificial metalloenzymes for diazo coupling cascade reactions. V. Valiante et al. elucidated the biosynthesis of fungal drimane-type sesquiterpene esters.

• Angewandte Chemie 44/2021: Breaking Limitations,
  Angew. Chem. Int. Ed. 2021, 60 (44).