In this issue, C. Lion et al. review bioimaging of cell contents. How can molecules in organelles be targeted? The Minireview deals with modulating the efficacy of carbonic anhydrase inhibitors through fluorine substitution (S. Thibaudeau et al.). S. Noda et al. share a Viewpoint on the proper reporting of turnover frequencies in electrocatalysis.

In the original research section, Y. Takemoto et al. report the total syntheses of shagenes A and B (see picture). M. Yu et al. describe the subsurface-carbon-induced local charge of copper for an on-surface displacement reaction. D. Tanaka et al. succeeded in the machine-learning-assisted selective synthesis of a semiconductive silver thiolate coordination polymer with segregated paths for holes and electrons. X. Guo et al. found a simple gas–solid treatment for surface modification of Li-rich oxides cathodes.

• Angewandte Chemie 43/2021: Image Inside,
  Angew. Chem. Int. Ed. 2021, 60 (43).