In this issue, R. Riedl et al. review medicinal chemistry strategies against drug resistance from a structural point of view. What mechanisms underly drug resistance? The Minireviews deal with the nucleophilicity of the B–H bonding pair electrons (X. Chen et al.), the thermodynamics of insertion electrochemical electrodes (F. Scholz, A. Doménech-Carbó), and the mechanochemistry of gaseous reactants (C. Bolm, J. G. Hernández). L. Dell’Amico and F. Zanardi highlight acetaldehyde silyl enol ethers in enantioselective Mukaiyama aldol reactions. In his Guest Editorial, G. R. Desiraju discusses what science and society owe each other.

In the Communications section, Y. Liu and S. Mecking present a synthetic polyester from plant oil feedstock which they obtained by functionalizing polymerization (see picture). J. F. Hartwig et al. introduce a multicatalytic approach to the hydroaminomethylation of α-olefins. U. Höfer et al. controlled an S_N2 reaction by electronic and vibrational excitation, namely the tip-induced ether cleavage on Si(001). S. Shima et al. describe how the bacterial [Fe]-hydrogenase paralog HMdII uses tetrahydrofolate derivatives as substrates.

• Angewandte Chemie 11/2019: Controlling Reactions,
  Angew. Chem. Int. Ed. 2019, 58 (11).