Teruaki Mukaiyama, formerly at Kitasato Institute, Tokyo, Japan, passed away on November 17, 2018. Professor Mukaiyama’s research focused on organic synthesis. He was best known for the Mukaiyama aldol addition [1], an aldol reaction between a silyl enol ether and an aldehyde. He also achieved a total synthesis of taxol [2].
Teruaki Mukaiyama was born on January 5, 1927, in Nagano, Japan. He studied chemistry at the Tokyo Institute of Technology and at the University of Tokyo, where he received his Ph.D. in 1957. He became Assistant Professor at the Tokyo Institute of Technology in 1958 and was promoted to Full Professor in 1963. In 1973, he moved to the University of Tokyo and in 1987, to the Tokyo University of Science. From 2002 to 2009, he served as Professor at Kitasato Institute.
Among other honors, Mukaiyama received the Chemical Society of Japan Award from the CSJ in 1973, the ACS Award for Creative Work in Synthetic Organic Chemistry from the American Chemical Society in 1996, the Tetrahedron Prize for Creativity in Organic Chemistry in 1998, and the Sir Derek Barton Gold Medal from the Royal Society of Chemistry in 2006. He was a Member of the Japan Academy and a Foreign Member of the Polish Academy of Sciences, the French Academy of Sciences, and of the U.S. National Academy of Sciences.
References
- [1] New Aldol Type Reaction,
Teruaki Mukaiyama, Koichi Narasaka, Kazuo Banno,
Chem. Lett. 1973, 2, 1011–1014.
https://doi.org/10.1246/cl.1973.1011 - [2] 3.0.CO;2-O” target=”_blank”>https://doi.org/10.1002/(SICI)1521-3765(19990104)5:1<121::AID-CHEM121>3.0.CO;2-O
Other Selected Publications
- Enantioselective Synthesis of 3,4-Dihydropyran-2-ones by Domino Michael Addition and Lactonization with New Asymmetric Organocatalysts: Cinchona-Alkaloid-Derived Chiral Quaternary Ammonium Phenoxides,
Takashi Tozawa, Hitoshi Nagao, Yoshinobu Yamane, Teruaki Mukaiyama,
Chem. Asian J. 2007, 2, 123–134.
https://doi.org/10.1002/asia.200600228 - Lewis Base-catalyzed Alkynylation of Carbonyl Compounds with Trimethylsilylacetylenes,
Takayuki Kitazawa, Tomofumi Minowa, Teruaki Mukaiyama,
Chem. Lett. 2006, 35, 1002–1003.
https://doi.org/10.1246/cl.2006.1002 - Lewis Base-Catalyzed Perfluoroalkylation of Carbonyl Compounds and Imines with (Perfluoroalkyl)trimethylsilane,
Yoshikazu Kawano, Nobuya Kaneko, Teruaki Mukaiyama,
Bull. Chem. Soc. Jpn. 2006, 79, 1133–1145.
https://doi.org/10.1246/bcsj.79.1133 - Enantioselective Trifluoromethylation of Ketones with (Trifluoromethyl)trimethylsilane Catalyzed by Chiral Quaternary Ammonium Phenoxides,
Hitoshi Nagao, Yoshikazu Kawano, Teruaki Mukaiyama,
Bull. Chem. Soc. Jpn. 2007, 80, 2406–2412.
https://doi.org/10.1246/bcsj.80.2406 - Effective Synthesis of 5-Substituted Butenolide Derivatives by Using Cinchonidine-derived Quaternary Ammonium Phenoxide Catalyst,
Hitoshi Nagao, Yoshinobu Yamane, Teruaki Mukaiyama,
Chem. Lett. 2007, 36, 8–9.
https://doi.org/10.1246/cl.2007.8 - Asymmetric Trifluoromethylation of Ketones with (Trifluoromethyl)trimethylsilane Catalyzed by Chiral Quaternary Ammonium Phenoxides,
Hitoshi Nagao, Yoshinobu Yamane, Teruaki Mukaiyama,
Chem. Lett. 2007, 36, 666–667.
https://doi.org/10.1246/cl.2007.666
