In this issue, C. Aymonier et al. review silicon-based dielectric metamaterials. What are the synthetic challenges? In a Minireview, L. Zhang and A. Vertes discuss single-cell mass spectrometry to explore cellular heterogeneity. The Highlight deals with stereoisomer selection by a [3]rotaxane host, and Jack Halpern‘s life and achievements are recorded in his Obituary.

In the Communications section, Z. Wu et al. describe the fourth alloying mode by way of anti-galvanic reaction (see picture). J. D. Brennan et al. present a paper sensor printed with multifunctional bio/nano materials. H. van Ingen et al. conducted site-specific studies of nucleosome interactions by solid-state NMR spectroscopy. N. Kim and R. A. Widenhoefer synthesized and characterized cationic gold diarylallenylidene complexes, and investigated their reactivity.

• Angewandte Chemie 17/2018: Challenges and Exploration,
  Angew. Chem. Int. Ed. 2018, 57 (17).