In this issue, L. Moroder and H.-J. Musiol review the history of and science behind insulin. What are the most recent advances of chemical synthesis that help assemble disulfide-bridged structures via biomimetic insulin precursors? In a Minireview, A. Brik et al. discuss the role of palladium in the chemical synthesis and modification of proteins. The Highlight deals with oligoarylene architecture (G. J. Bodwell). P. Ayers and W. Yang eulogize Robert G. Parr, one of the founders of quantum chemistry.

In the Communications section, S. Che at al. describe a silica scaffold with shifted networks and their interconversion into diamond networks (see picture). A. Dömling et al. succeeded in the two-step synthesis of complex artificial macrocyles. M. Arndt et al. report on the quantum-assisted metrology of neutral vitamins in the gas phase.

• Angewandte Chemie 36/2017: Building Bridges,
  Angew. Chem. Int. Ed. 2017, 56 (36).