In this issue, F. Merino and S. Raunser review electron cryo-microscopy as a tool for structure-based drug development. How can structures of pharmacologically relevant macromolecules be elucidated that have escaped classical techniques? In a further review, B. M. Trost and M. C. Ryan discuss the role of indenylmetal catalysis in organic synthesis. What are the advantages over the related cyclopentadienyl compounds? The Highlight deals with enabling heterogeneous gold catalysis with patchy micelles (I. Manners). In her Editorial, former editorial board member Brigitte Voit explores options to bring new polymers with beautiful structures to market.

In the Communications section, I. Krossing et al. present the parent cyclopentadienyltin cation, its toluene adduct and the quadruple-decker [Sn₃Cp₄]²⁺ (see picture). K.-W. Park et al. demonstrate high performance of a chemically regenerative redox fuel cell by using a NO₃⁻/NO reaction. Y. Zhu et al. succeeded in the construction of nine-membered heterocycles through palladium-catalyzed formal [5+4] cycloaddition. L. G. Delogu et al. report that few-layer graphene selectively kills tumor cells from leukemia patients.

• Angewandte Chemie 11/2017: Escape from Classical Techniques,
  Angew. Chem. Int. Ed. 2017, 56 (11).