2-benzoxopinones were synthesized by a dual activation strategy, involving N-heterocyclic carbene catalysis and a second Lewis base

Enantioselective Carbene-Catalyzed Annulations

Next-Generation of Histone Deactylase Inhibitors
A new series of ruthenium complexes that act as histone deacetylase (HDAC) inhibitors show promise as anticancer agents

Extracting the Medicine from Traditional Chinese Medicine
Isolated compounds from Chinese medicine often show physiological activity. One such compound from Gansong has been identified

Malleobactin Structure Elucidated
The virulence factor malleobactin has been shown to contain an unprecedented nitro-bearing amino acid

Roughing up Smoothened
A second-generation Smoothened (Smo) antagonist has shown excellent efficacy in rodent tumor models

History of Cyclotides
Cyclotides are head-to-tail cyclic peptides in plants

Discussing US Toxic Substances Control Act (TSCA)
A Center for International Environmental Law (CIEL) study finds that stricter rules over hazardous chemicals inspire the innovation

A Spontaneous Resolution
Chiral supramolecular fluorophores can be made by simple crystallisation

Job: Assistant Editor Wiley-VCH's Physics Journals
Explore a career in publishing: Assistant Editor, Wiley-VCH's physics journals

Graphene Onion Rings
Tiny sliced onion three-dimensional (3D) rings of graphene have been produced and investigated