In this issue, M. Braun et al. review non-immunosuppressive cyclophilin inhibitors, and S. Wang et al. summarize microenvironment engineering for the electrocatalytic CO₂ reduction, also in a Review. The Minireview deals with task-specific Janus materials in heterogeneous catalysis (M. Vafaeezadeh, W. R. Thiel). In a Scientific Perspective, G. R. Desiraju et al. discuss heterosynthons, solid form design, and enhanced drug bioavailability. S. Lütz et al. highlight cascades of evolved enzymes for the synthesis of complex molecules.

In the original research section, P. Gerdt and A. Studer demonstrate synthesis of alternating terpolymers through cyclopolymerization and subsequent orthogonal functionalization (see picture). R. Deprez-Poulain et al. discovered selective nanomolar inhibitors of ERAP2 by kinetic target-guided synthesis. A. Beloqui et al. developed a versatile chemoenzymatic nanoreactor that mimics NAD(P)H oxidase for the in situ regeneration of cofactors. J. A. Rodriguez et al. investigated the interaction of K and O₂ on Au(111) and found multiple growth modes of potassium oxide and their catalytic activity for CO oxidation. J. Chen et al. designed quinone-based anodes with rapid kinetics for rechargeable proton batteries.

• Angewandte Chemie 39/2022: Versatile Reactors,
  Angew. Chem. Int. Ed. 2022, 61 (39).