In this issue, Ben L. Feringa et al. discuss rational design in photopharmacology with molecular photoswitches in a Review, and Khalid Salaita et al. review DNA nanotechnology for the investigation of mechanical signaling in the immune system. The Minireviews deal with regioselective difunctionalization and annulation of ynamide (Akhila K. Sahoo et al.) and the nephelauxetic effect as an important design factor for photo-active first-row transition metal complexes (Oliver S. Wenger et al.). In a Viewpoint Article, Annette Trunschke et al. outline strategies for data acquisition, storage, and use to achieve digital catalysis.

In the original research section, Shengqian Ma et al. show how to tune the local charge distribution in multicomponent covalent organic frameworks to dramatically enhance photocatalytic uranium extraction (see picture). Hong-Ying Zang et al. designed tetranuclear iron-oxo clusters with redox activity for high-performance lithium storage. Mark J. MacLachlan et al. created molecular flytraps held together by platinum–platinum intermetallic bonds. Elena Fernández et al. explain the new concept behind the boryl migration from C(sp²) in alkenyl boranes to C(sp³) in boron–copper 1,3-rearrangements.

• Angewandte Chemie 30/2023: Rational Design,
  Angew. Chem. Int. Ed. 2023, 62 (30).

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