Lutz F. Tietze, University of Göttingen, Germany, celebrates his 75th birthday on March 14, 2017.
Professor Tietze’s research is focused on synthetic organic and medicinal chemistry. He aims to develop new synthetic methods with high efficiency and selectivity for the total synthesis of bioactive natural products, as well as novel approaches for the treatment of cancer using antibody directed enzyme prodrug therapy (ADEPT), prodrug monotherapy (PMT), and antibody drug conjugates (ADCs).
Lutz F. Tietze studied chemistry at the Universities of Kiel and Freiburg, both Germany. He received his Ph.D. for work on the selective oxidation of laudanosolin derivatives under the supervision of Burchard Franck in 1968. After stays as Research Associate with George Büchi at the Massachusetts Institute of Technology (MIT), Cambridge, USA, and with Alan R. Battersby at Cambridge University, UK, Tietze completed his habilitation at the University of Münster, Germany, in 1975. He joined the University of Dortmund, Germany, as Professor in 1977 and moved to the University of Göttingen in 1978. Since 2012, Tietze is Distinguished Research Professor of the State of Lower Saxony, Germany.
Among other honors, Tietze has received the Literature Prize of the German Chemical Industry Fund (Fonds der Chemischen Industrie, FCI) in 1982, an honorary doctorate from the University of Szeged, Hungary, in 1994, the Grignard-Wittig-Award from the Société Chimique de France (SCF, French Chemical Society) in 2002, and the Emil Fischer Medal from the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society) in 2004. He is a Member of the Academy of Science, Göttingen, a Corresponding Member of the North Rhine-Westphalian Academy of Sciences and the Arts, a Fellow of the Royal Society of Chemistry, and an Honorable Fellow of the Indian Chemical Society (CSRI).
Selected Publications
- In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1,
Joanna Napp, Luis A. Pardo, Franziska Hartung, Lutz F. Tietze, Walter Stühmer, Frauke Alves,
Eur. Biophys. J. 2016, 45, 721–733.
DOI: 10.1007/s00249-016-1152-z - Reactions and Syntheses: In the Organic Chemistry Laboratory,
Lutz F. Tietze, Theophil Eicher, Ulf Diederichsen, Andreas Speicher, Nina Schutzenmeister,
Wiley-VCH, Weinheim, 2015.
ISBN: 978-3-527-33814-6 - Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues,
Maximilian F. Koch, Sabrina Harteis, Iris D. Blank, Galina Pestel, Lutz F. Tietze, Christian Ochsenfeld, Sabine Schneider, Stephan A. Sieber,
Angew. Chem. Int. Ed. 2015, 54, 13550–13554.
DOI: 10.1002/anie.201505749 - Enantioselective Total Synthesis of Secalonic Acid E,
Dhandapani Ganapathy, Johannes R. Reiner, Lorenz E. Löffler, Ling Ma, Boopathy Gnanaprakasam, Benedikt Niepötter, Ingo Koehne, Lutz F. Tietze,
Chem. Eur. J. 2015, 21, 16807–16810.
DOI: 10.1002/chem.201503593 - Formal Synthesis of (–)-Siccanin Using an Enantioselective Domino Wacker/Carbonylation/Methoxylation Reaction,
Lutz Tietze, Stefan Jackenkroll, Dhandapani Ganapathy, Johannes Reiner,
Synlett 2015, 27, 96–100.
DOI: 10.1055/s-0035-1560752 - Domino Reactions: Concepts for Efficient Organic Synthesis,
Lutz F. Tietze (Ed.),
Wiley-VCH, Weinheim, 2014.
ISBN: 978-3-527-33432-2 - Synthesis and Photochemical Investigations of Tetrasubstituted Alkenes as Molecular Switches – The Effect of Substituents,
Lutz F. Tietze, M. Alexander Düfert, Tim Hungerland, Kawon Oum, Thomas Lenzer,
Chem. Eur. J. 2011, 17, 8452–8461.
DOI: 10.1002/chem.201003559 - Synthesis of Chiroptical Molecular Switches by Pd-Catalyzed Domino Reactions,
Lutz F. Tietze, Alexander Düfert, Florian Lotz, Lars Sölter, Kawon Oum, Thomas Lenzer, Tobias Beck, Regine Herbst-Irmer,
J. Am. Chem. Soc. 2009, 131, 17879–17884.
DOI: 10.1021/ja906260x - Enantioselective Palladium-Catalyzed Total Synthesis of Vitamin E by Employing a Domino Wacker–Heck Reaction,
Lutz F. Tietze, Florian Stecker, Julia Zinngrebe, Konrad M. Sommer,
Chem. Eur. J. 2006, 12, 8770–8776.
DOI: 10.1002/chem.200600849 - Domino Reactions in Organic Synthesis,
Lutz F. Tietze, Gordon Brasche, Kersten Gericke,
Wiley-VCH, Weinheim, 2006.
ISBN: 978-3-527-29060-4
Also of Interest
- A Fast Way to Fluorescence,
Hayley Charville,
ChemViews Mag. 2014.
A fourfold domino reaction to condensed polycyclic compounds - A Domino Approach to Total Synthesis,
Hayley Charville,
ChemViews Mag. 2014.
The first enantioselective total syntheses of blennolide C and gonytolide C are reported
