Irwin Rose, one of the 2004 Nobel Laureates in Chemistry, has passed away on June 2.
Rose received the Nobel Prize together with Aaron Ciechanover and Avram Hershko for the discovery of ubiquitin-mediated protein degradation. Ubiquitin (ubiquitous immunopoietic polypeptide) is a small protein that can be attached to other proteins and marks them for breakdown by the proteasome.
Irwin Rose attended Washington State University, Pullman, WA, USA, and the University of Chicago, IL, USA, where he received his bachelor’s degree in 1948 and his Ph.D. in biochemistry in 1952. He joined the Yale School of Medicine, New Haven, CT, USA, as Instructor in Biochemistry in 1954. From 1963, he worked in basic research at the Institute for Cancer Research of the Fox Chase Cancer Center, Philadelphia, PA, USA, and stayed there until he retired in 1995.
Selected Publications
- Mechanistic Inferences from Stereochemistry,
I. A. Rose,
J. Biol. Chem. 2006, 281, 6117–6119.
DOI: 10.1074/JBC.X600001200 - Ubiquitin at Fox Chase (Nobel Lecture),
Irwin Rose,
Angew. Chem. Int. Ed. 2005, 44 (37), 5926–5931.
DOI: 10.1002/anie.200500995 - Methylglyoxal Synthetase, Enol-Pyruvaldehyde, Glutathione and the Glyoxalase System,
Irwin A. Rose, James S. Nowick,
J. Am. Chem. Soc. 2002, 124, 13047–13052.
DOI: 10.1021/ja027065h - How Fumarase Recycles after the Malate – Fumarate Reaction. Insights into the Reaction Mechanism,
Irwin A. Rose,
Biochemistry 1998, 37, 17651–17658.
DOI: 10.1021/bi9821521 - Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.,
A. Hershko, A. Ciechanover, H. Heller, A. L. Haas, I. A. Rose,
Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 1783–1786.
DOI: 10.1073/pnas.77.4.1783
Also of Interest
- Avram Hershko: Curiosity and Persistence,
Vera Koester,
ChemViews Mag. 2013.
DOI: 10.1002/chemv.201300106
Nobel Laureate Avram Hershko discusses how curiosity, choosing the right research, and persistence are general principles for success
