Lynne E. Maquat, University of Rochester, NY, USA, has received the Wiley Prize in Biomedical Sciences 2018 for elucidating the mechanism of nonsense-mediated messenger RNA decay, a process which cells use to prevent the production of toxic proteins. The prize is presented annually to recognize contributions that have opened new fields of research or have advanced concepts in a particular biomedical discipline. It includes a prize money of USD 50,000. The award was presented at a prize luncheon at Rockefeller University, New York, USA, on April 13, 2018.
Lynne E. Maquat studied biology at the University of Connecticut, Storrs, USA, and received her Ph.D. in biochemistry from the University of Wisconsin–Madison, USA, in 1979. She is Professor at the Department of Biochemistry and Biophysics of the School of Medicine and Dentistry as well as the J. Lowell Orbison Endowed Chair at the University of Rochester, Director of the Center for RNA Biology at the University of Rochester Medical Center, and Founding Chair of the University of Rochester Graduate Women in Science (GWIS).
Among other honors, Maquat received the William C. Rose Award from the American Society for Biochemistry & Molecular Biology in 2014, the International RNA Society Lifetime Achievement Award in Service in 2010 and in Science in 2017, the Vanderbilt Prize in Biomedical Sciences in 2017, and the Federation of American Societies for Experimental Biology (FASEB) Excellence in Science Award in 2018. She is an elected Member of the American Academy of Arts & Sciences, the U.S. National Academy of Sciences, and the U.S. National Academy of Medicine.
Selected Publications
- Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay,
Bronwyn A. Lucas, Eitan Lavi, Lily Shiue, Hana Cho, Sol Katzman, Keita Miyoshi, Mikiko C. Siomi, Liran Carmel, Manuel Ares, Lynne E. Maquat,
Proc. Natl. Acad. Sci. USA 2018, 115, 968–973.
https://doi.org/10.1073/pnas.1715531115 - UPF1 helicase promotes TSN-mediated miRNA decay,
Reyad A. Elbarbary, Keita Miyoshi, Omar Hedaya, Jason R. Myers, Lynne E. Maquat,
Genes Dev. 2017, 31, 1483–1493.
https://doi.org/10.1101/gad.303537.117 - Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism,
Reyad A Elbarbary, Lynne E. Maquat,
Nat. Struct. Mol. Biol. 2017, 24, 496–498.
https://doi.org/10.1038/nsmb.3416 - lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements,
Chenguang Gong, Lynne E. Maquat,
Nature 2011, 470, 284–288.
https://doi.org/10.1038/nature09701 - Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics,
Lynne E. Maquat,
Nat. Rev. Mol. Cell Biol. 2004, 5, 89–99.
https://doi.org/10.1038/nrm1310 - The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions,
Hervé Le Hir, Elisa Izaurralde, Lynne E. Maquat, Melissa J. Moore
EMBO J. 2000, 19, 6860–6869.
https://doi.org/10.1093/emboj/19.24.6860
Also of Interest
